Xeloda in combination with docetaxel resulted in statistically significant improvement in time to disease progression, overall survival and objective response rate compared to monotherapy with docetaxel as shown in table 17 , figure 4 , and figure 5.
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The concentration of 5-fluorouracil is increased and its toxicity may be enhanced by leucovorinDeaths from severe enterocolitisdiarrheaand dehydration have been reported in elderly patients receiving weekly leucovorin and fluorouracil.
Table 9 Percent Incidence of Adverse Reactions Considered RemotelyPossibly or Probably Related to Treatment in5of Patients Participating in the Single Arm Trial in Stage IV Breast Cancer.
It is administered orally in the form of tabletswhich are usually taken twice a day with plenty of waterThe dosage is defined according the characteristics of both tumor and patientbut the treatment usually consist of several cyclesAfter being ingestedthe body transforms capecitabine tablets into the common chemotherapy drug fluorouracil.
Dehydration has been observed and may cause acute renal failure which can be fatalPatients with preexisting compromised renal function or who are receiving concomitant XELODA with known nephrotoxic agents are at higher riskPatients with anorexiaasthenianauseavomiting or diarrhea may rapidly become dehydratedMonitor patients when XELODA is administered to prevent and correct dehydration at the onsetIf grade 2or higherdehydration occursXELODA treatment should be immediately interrupted and the dehydration correctedTreatment should not be restarted until the patient is rehydrated and any precipitating causes have been corrected or controlledDose modifications should be applied for the precipitating adverse event as necessarysee DOSAGE AND ADMINISTRATION
The chemical name for capecitabine is 5deoxy-5-fluoro-Npentyloxycarbonylcytidine and has a molecular weight of 359.35Capecitabine has the following structural formula:
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you should not take generic for xeloda 500mg capecitabine 500mg if you are allergic to capecitabine or fluorouracil adrucil , or if you have severe kidney disease or a metabolic disorder called dpd dihydropyrimidine dehydrogenase deficiency.