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The exposure of the hydroxybupropion metabolite was decreased by 78 , the threohydrobupropion decreased by 50 , and the erythrohydrobupropion decreased by 68 .

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Assess blood pressure before initiating treatment with sustained release formulationand monitor periodically during treatmentrisk of hypertension is increased if sustained release formulation is used concomitantly with MAOIs or other drugs that increase dopaminergic or noradrenergic activityuse caution in patients with cardiovascular disease.

This prescription medication may also be used as a treatment to manage attention deficit hyperactivity disorderADHDIt may also be used as a prescription treatment to help people quit smoking by decreasing cravings and nicotine withdrawal effectsIt may be used to prevent autumn-winter seasonal depressionseasonal affective disorderThis drug may also be used with other medications as a treatment for bipolar disorderdepression phaseIt may also be used to treat anxiety in people with depression.

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